Improved tools for investigating the intestinal uptake and subsequent immune and endocrine responses to novel dietary proteins.

There is an urgent need to identify alternative sustainable sources of dietary protein in order to meet the demands of the world’s growing population. Such new protein sources may modulate gut hormonal and mucosal functioning in an unpredictable manner, and have unintended metabolic and immunological effects, such as introducing novel food allergens into the diet. Effective in vitro gut models are lacking but would facilitate mechanistic studies on these effects and provide much needed tools to allow screening for beneficial/adverse effects of novel proteins. Pump-priming funding is required to undertake feasibility studies to obtain the preliminary data required to make credible joint multidisciplinary multi-centre applications for funding which will meet the emerging research and innovation priorities of UKRI. Industry collaboration is embedded from the outset, demonstrating the capacity of the consortium as a whole to work together and ensure effective and rapid adoption of new technology as set out in the Green paper on industrial strategy.

PI: Professor Clare Mills, The University of Manchester